Are you looking for toenail fungus topical treatment that works?

Perhaps, you are one of hundreds of people looking for toenail fungus topical treatment that works. Nail fungus or onychomycosis is a disease difficult to cure with topical medications applied to the nail. This is because the drug is difficult to penetrate layers of water-resistant nails when fungus often hides in the deepest layers of the nail. Some oral drugs can penetrate the layers of the nail with a sufficiently high concentration but anti-fungal medications can cause systemic side effects which are quite dangerous, such as liver damage. Therefore, many people hope to recover from toenail fungus with topical treatment.

Is there toenail fungus topical treatment that proven by clinical trials?

Since long, the FDA has approved ciclopirox, often known as penlac nail lacquer to treat mild to moderate nail fungus. Treatment with penlac cannot be used if the fungus infection has spread to the lunula or nail bed. Although used as a standard for topical treatment, ciclopirox no better effectiveness compared with oral treatment for toenail fungus.

Is there toenail fungus topical treatment which more effective than ciclopirox?

Amorolfine nail lacquer topical treatment for toenail fungus
To date, there has been no clinical trial comparing the effectiveness of amorolfine and ciclopirox in curing toenail fungus. From the economic point of view, several studies have shown that amorolfine is more efficient than ciclopirox. Amorolfine can be applied just once a week for 6 months due to amorolfine could penetrate the nail layer and persist in it until seven days. Side effects due to topical treatment with amorolfine are very little. The most common side effects encountered include itching, burning, erythema and scaling.

Tioconazole topical treatment
In the 80s, tioconazole is the drug of choice for toenail fungus treatment. At that time, the drug is more effective than miconazole. However, today tioconazole is no longer recommended.

Salicylic acid for toenail fungus
Although many over the counter drug containing salicylic acid, and said that this substance is effective in treating nail fungus, research has not shown that salicylic acid can cure for toe nail fungus. Salicylic acid is not recommended for toenail fungus topical treatment.

Undecenoates or Undecylenic acid
There are no clinical trials proving that Undecylenic acid can cure toenail fungus. However, the combination Undecylenic acid, cyanoacrylates and hydroquinones have been shown to cure fungal nail infections. In fact, the combination of the three substances is more effective than ciclopirox, toenail fungus topical treatment that is known in advance.

Herbs Topical Treatment for Toenail Fungus
Some herbs have also been shown to cure nail fungus. Herbal remedies,such as tea tree oil, have the same effectiveness with ciclopirox. If further developed, herbs can be an alternative to topical treatment for toenail fungus.

Although several studies have shown that topical treatment is quite effective in curing nail fungus, oral treatment remained superior. AAFP recommend a toenail fungus topical treatment used as adjuvant therapy to oral medications.

Source:
Evidence on topical treatments for dermatophyte onychomycosis. NHS Clinical Knowledge Summaries

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