Snakeroot, Mexican Plants as toenail fungus natural cure, a scientific evidence

Since a few decades ago, snakeroot has been used to treat superficial toenail fungus. These plants are believed to be a natural remedy for several skin diseases. Extracts from snakeroot leaves is applied topically on fungus-infected areas. We can use either fresh leaves or leaves that have been dried. Then, the leaves are extracted with alcohols so we can use active substances contained in them as a topical treatment for toenail fungus.

Research conducted at the Biomedical Laboratory of the Instituto Mexicano del Seguro Social shown that extracts of this plant can inhibit the growth of fungi. The researchers examine the antifungal activity of some plant extracts against some dermatophyte fungi, nondermatophyte fungi, and yeast, such as Trichophyton mentagrophytes, Trichophyton rubrum, Aspergillus niger, and Candida albicans. Of the several types of plants, leaf extracts of plants from the Asteraceae species have the most potent substances to inhibit the growth of Trychophyton, most causes of toenail fungus. Based on these findings, some researchers from the same institution entered into a clinical trial to prove the effectiveness of leaf extract Snakeroot (Ageratina pichinchensis) to treat nail fungus. In a study involving 96 subjects, the effectiveness of Ageratina pichinchensis extract in treating Trichophyton rubrum infections compared with ciclopirox (Penlac). Forty-nine nail fungus patients were treated with nail lacquer containing encecalin, active compound from Snakeroot leaf extract. This natural treatment lasts for six months. Meanwhile, forty-seven other people were given 8% ciclopirox topically. The research results showed Snakeroot leaf extract has more than 70% therapeutic effectiveness. Encecalin therapeutic effectiveness is not much different with ciclopirox ( Penlac ). The results of this study provide hope that natural nail fungus treatment is not inferior to topical treatment with chemicals.

Effectiveness of snakeroot leaf extract in treating nail fungus naturally which is quite satisfactory, encourage researchers to explore natural remedies to treat fungal infections of the nails. Research to find out What is the most effective leaf extract concentration to cure toenail fungus were carried out. Researchers compared the effectiveness of the nail lacquer containing 12.6% and 16% extract of Ageratina pichinchensis. The result, both natural treatment is quite effective in combating nail fungus, although the 16.8% concentration of extract have higher effectiveness. The side effects are also not found in both groups. Natural treatment with extracts of Snakeroot more promising than Penlac. With the active content is lower than ciclopirox, the effectiveness of natural remedies is no less than Penlac. Concentration of leaf extract with 12.6% only contain 1.81% bioactive content while 16.8% leaf extract contains 2.41% encecalin. This is much lower than active compound of ciclopirox which up to 8%. These lower levels of active compound are expected to have minimal side effects.

According to some researches, we can conclude that natural treatment with leaf extract Snakeroot can be alternative therapies to treat nail fungus. Use of leaf extract topically for six months effective enough to eradicate the fungal infection. Unlike Penlac topical treatment that has side effects, these natural treatments do not cause side effects. You can discuss this natural alternative remedies for nail fungus with your doctor.


Navarro García VM, Gonzalez A, Fuentes M, Aviles M, Rios MY, Zepeda G, Rojas MG. 2003. Antifungal activities of nine traditional Mexican medicinal plants. J Ethnopharmacol 87, 85-88.

Romero-Cerecero O, Román-Ramos R, Zamilpa A, Jiménez-Ferrer JE, Rojas-Bribiesca G, Tortoriello J., 2009. Clinical trial to compare the effectiveness of two concentrations of the Ageratina pichinchensis extract in the topical treatment of onychomycosis. J Ethnopharmacol 126, 74-78.

Romero-Cerecero, O., Zamilpa, A., Jiménez-Ferrer, J.E., Rojas-Bribiesca, M.G., Román-Ramos, R., Tortoriello, J., 2008. Double-blind clinical trial for evaluating the effectiveness and tolerability of Ageratina pichinchensis extract on patients with mild to moderate onychomycosis. A comparative study with ciclopirox. Planta Medica 74, 1430–1435.

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