Amphotericin B for Non-Dermatophyte Nail Fungus Clinical Evidence

Although rare, non-dermatophyte fungi can also cause toenail fungus on the abnormal nail. Unfortunately, non-dermatophyte fungi can not be treated with the same treatment for nail fungus which caused by dermatophyte. Fusarium sp and several other species are resistant to standard treatment for nail fungus treatments both topical and oral medications such as Lamisil and Sporanox. Therefore, the diagnosis of nail fungus is very important to be aware of fungi species that cause nail fungus and provide the most appropriate treatment.

Amphotericin B for non-dermatophyte nail fungus reasearch 2012

In a study published in January 2012, researchers from Switzerland have shown that amphotericin B is an effective topical treatment for non dermatophyte nail fungus. Topical treatment with amphotericin B is very practical. Solution of amphotericin B can be applied once daily on the infected nail and surrounding tissue. This treatment does not require nail debridement. Urea cream also can be applied to help soften the thickened nails due to fungal infection. Within 12 months, all patients involved in the study, get clinical cure from nail fungus. A microbiological cure rate is also quite high reaching 87.5%. In addition to practical, treatment with amphotericin B is also cheap. Amphotericin B for non-dermatophyte nail fungus does not cause side effects.

Amphotericin B for non-dermatophyte nail fungus – nothing is perfect

Although the clinical cure rate reaches 100%, evidence of the greatness of amphotericin B for non-dermatophyte nail fungus can still be improved. This study involves only a few subjects that is 8 people. In addition, amphotericin B treatment for nail fungus also requires patience because it takes a year.

Source:
Efficacious Treatment of Non-Dermatophyte Mould Onychomycosis with Topical Amphotericin B [Pubmed]

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